vävnadsfaktorfaktor
Vävnadsfaktorfaktor, often abbreviated as TF, is a transmembrane protein that plays a crucial role in the initiation of the blood coagulation cascade. Also known as thromboplastin or factor III, it is primarily found on the surface of cells outside the blood vessels, such as fibroblasts and smooth muscle cells. When a blood vessel is injured, TF is exposed to the circulating blood.
Upon exposure, TF binds to activated factor VII (FVIIa), forming a complex that activates factor X (FX)
TF's role is not limited to hemostasis; it also participates in other physiological and pathological processes,