volatiilsem
Volatiilsem is a recently introduced class of high‑volatile, self‑emulsifying drug delivery systems (SEDDS) designed for oral administration of poorly soluble therapeutics. The term combines “volatile” with “sem” for self‑emulsifying micelle, highlighting the system’s rapid dispersion and ease of absorption. Volatiilsem formulations typically contain a low‑molecular‑weight oil phase, a surface‐active emulsifier, and a co‑solvent that enhances the solubility of lipophilic APIs. Upon contact with gastrointestinal fluids, the mixture generates a fine emulsion with droplet diameters below 100 nm, which facilitates lymphatic transport and bypasses first‑pass metabolism.
The key property of volatiilsem is its volatility. The co‑solvent evaporates quickly, allowing the emulsifier to
Volatiilsem has seen application in the delivery of macrolide antibiotics, statins, and certain antidiabetic agents where
Because the formulation components are generally regarded as safe by regulatory agencies, volatiilsem is considered a