vinkristiini

Vincristine, also known by its trade name Oncovin, is an alkaloid derived from the plant Catharanthus roseus, commonly known as Madagascar periwinkle. It is a potent antineoplastic agent used primarily in the treatment of various types of cancer. Vincristine works by inhibiting microtubule assembly, which is essential for cell division and growth. This mechanism of action makes it effective against a range of cancers, including leukemia, lymphoma, and certain solid tumors.

Vincristine was first isolated in the 1960s and has since been a cornerstone in cancer chemotherapy. It is typically administered intravenously and is often used in combination with other chemotherapeutic agents to enhance its efficacy and reduce the risk of resistance. Common side effects of vincristine include peripheral neuropathy, which can cause numbness and weakness in the hands and feet, and myelosuppression, which affects the bone marrow and can lead to anemia and infections.

The drug is available in various formulations, including tablets and injectable solutions. Its use is closely monitored by healthcare providers to manage potential side effects and optimize treatment outcomes. Research continues to explore new applications and combinations of vincristine to improve its therapeutic index and reduce toxicity.