vaborbaktam
Vaborbaktam is a boron-containing beta-lactamase inhibitor used in combination with the carbapenem antibiotic meropenem to treat certain resistant bacterial infections. It is marketed in combination as meropenem/vaborbaktam under the brand name Vabomere.
Mechanism and spectrum: Vaborbaktam inhibits serine beta-lactamases, notably class A enzymes such as KPC and some
Clinical use: Meropenem/vaborbaktam is indicated for adults with complicated urinary tract infections, including acute pyelonephritis, and
Safety and resistance: Common adverse effects resemble those of other beta-lactams and may include nausea, headache,
Pharmacokinetics: Both components are primarily eliminated renally, necessitating dose adjustments for impaired kidney function.