v1a1

v1a1 is a gene that encodes a protein belonging to the voltage-gated calcium channel superfamily. Specifically, it is a subunit of the P/Q-type calcium channel. This channel plays a crucial role in neurotransmitter release at synapses in the nervous system. The protein produced by v1a1 is essential for the proper functioning of neuronal communication.

Mutations in the v1a1 gene have been associated with certain neurological disorders. Research has linked variations in this gene to conditions such as familial hemiplegic migraine type 1 (FHM1), a severe form of migraine with aura that is inherited. These mutations can lead to altered calcium channel function, impacting neuronal excitability and leading to symptoms like temporary paralysis. Studies on v1a1 are ongoing to further understand its precise mechanisms and potential therapeutic targets for related disorders. The distribution and specific roles of v1a1 in different brain regions are also areas of active investigation.