tumorantigens
Tumorantigens are molecules expressed on the surface of cancer cells that can be recognized by the immune system. They are essential for the development of strategies that aim to clear malignant cells by harnessing the body’s own defenses.
The term covers two interconnected groups. Tumor‑associated antigens (TAAs) are normally present at low levels in
The recognition of tumorantigens is a key step in cancer immunosurveillance. Failure to eliminate cells bearing
Clinical investigations have identified several prominent tumorantigens. Examples include NY‑ESO‑1 and MAGE‑A4, which are restricted to
Therapeutic approaches that target tumorantigens range from peptide vaccines to engineered T‑cell receptors and chimeric antigen