tsDMARDlääkkeistä
tsDMARDlääkkeet, or targeted synthetic disease-modifying antirheumatic drugs, represent a class of medications used to treat inflammatory autoimmune diseases, most notably rheumatoid arthritis. Unlike traditional DMARDs, tsDMARDs are designed to selectively inhibit specific molecules involved in the inflammatory pathways of these conditions. The most prominent group within tsDMARDs are the Janus kinase (JAK) inhibitors. JAKs are intracellular enzymes that play a crucial role in signaling pathways for cytokines, which are proteins that promote inflammation. By blocking JAKs, these drugs interfere with the signals that drive inflammation and joint damage.
The development of tsDMARDs marked a significant advancement in the management of inflammatory diseases, offering a