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Triphenylphosphine oxide is an organophosphorus compound with the chemical formula (C6H5)3PO. It is a white crystalline solid that is soluble in organic solvents but insoluble in water. Triphenylphosphine oxide is commonly used as a ligand in coordination chemistry and as a precursor to other phosphorus-containing compounds.

The compound is typically prepared by the oxidation of triphenylphosphine using hydrogen peroxide or other oxidizing agents. It can also be synthesized by the reaction of triphenylphosphine with oxygen in the presence of a catalyst. Triphenylphosphine oxide is a versatile reagent in organic synthesis, often used in the preparation of phosphine oxides and other phosphorus-containing compounds.

In coordination chemistry, triphenylphosphine oxide acts as a ligand, forming complexes with transition metals. These complexes are often used as catalysts in various chemical reactions. The compound is also used in the synthesis of pharmaceuticals and other organic compounds.

Triphenylphosphine oxide is generally considered to be non-toxic, but like all chemicals, it should be handled with care. Proper safety precautions should be taken when working with the compound, including the use of personal protective equipment and the disposal of waste materials in accordance with local regulations.