topotécane

Topotecan is a medication used in cancer treatment. It belongs to a class of drugs called topoisomerase inhibitors. Specifically, it is a semi-synthetic derivative of camptothecin, a natural compound. Topotecan works by inhibiting topoisomerase I, an enzyme essential for DNA replication and repair. By interfering with this enzyme, topotecan causes DNA damage in rapidly dividing cancer cells, ultimately leading to their death.

This drug is primarily administered intravenously. It is often prescribed for the treatment of certain types of cancer, most notably ovarian cancer that has recurred after initial chemotherapy. It is also used for small cell lung cancer, particularly when the disease has advanced. The dosage and duration of treatment depend on the specific cancer, the patient's overall health, and their response to the medication.

As with many chemotherapy agents, topotecan can cause side effects. Common side effects include bone marrow suppression, leading to low blood cell counts (neutropenia, anemia, thrombocytopenia), which can increase the risk of infection and bleeding. Other potential side effects may include nausea, vomiting, diarrhea, hair loss, and fatigue. Medical professionals closely monitor patients receiving topotecan to manage these side effects and assess the effectiveness of the treatment.