topoisomerasebinding
Topoisomerase binding refers to the interaction between topoisomerase enzymes and DNA. Topoisomerases are a class of enzymes essential for DNA replication, transcription, and repair. They function by altering the topological state of DNA, which involves managing the supercoiling and knotting of the DNA molecule. This is achieved by introducing transient breaks in the DNA backbone, allowing the DNA to untangle, and then resealing the breaks.
The binding of topoisomerase to DNA is a critical step in this process. The enzyme recognizes specific
The binding affinity and specificity of topoisomerases for DNA can be influenced by various factors, including