tetramerbased
Tetramerbased refers to systems and approaches that rely on tetrameric assemblies—complexes formed by four subunits—to achieve functional properties. Tetramers can be homo-tetramers, comprising four identical subunits, or hetero-tetramers, consisting of four different components. The quaternary structure enables cooperative interactions, increased stability, and multivalent binding that can enhance affinity and specificity in various contexts.
In immunology, tetramerbased approaches are well established through peptide–MHC tetramers used to detect antigen-specific T cells.
In biochemistry and structural biology, many natural proteins function as tetramers, including hemoglobin, which exhibits cooperative
Production and design commonly involve genetic fusion to enforce assembly, or chemical crosslinking and affinity-based scaffolding