tertbutyldiphenyylisilankloridi

tert-Butyldiphenylphosphine is an organophosphorus compound with the chemical formula (C₆H₅)₂P(C(CH₃)₃). It is a phosphine ligand that is widely used in homogeneous catalysis. The bulky tert-butyl group provides steric hindrance, which can influence the reactivity and selectivity of catalytic reactions. It is often employed in cross-coupling reactions such as Suzuki, Heck, and Buchwald-Hartwig amination. The electronic properties of the ligand can also be tuned by modifying the phenyl groups, although in the standard tert-butyldiphenylphosphine, these are unsubstituted.

This ligand is known for its stability and ease of handling compared to some other phosphine ligands. It is typically a white crystalline solid. Its synthesis usually involves the reaction of chlorodiphenylphosphine with tert-butylmagnesium chloride or a similar Grignard reagent. The steric bulk of the tert-butyl group is key to its utility in catalysis, as it can promote reductive elimination and prevent catalyst deactivation pathways. It is soluble in many organic solvents, which facilitates its use in various reaction media. Its application has contributed to the development of more efficient and selective synthetic methods in organic chemistry.