tablettenbindemittel

Tablettenbindemittel, also known as tablet excipients, are inactive substances used in the formulation of tablets to achieve desired physical and chemical properties. They play a crucial role in the manufacturing process by acting as fillers, binders, disintegrants, lubricants, and glidants. Fillers, such as lactose or microcrystalline cellulose, occupy space in the tablet and contribute to its bulk. Binders, like starch or gelatin, hold the active pharmaceutical ingredients together and provide structural integrity. Disintegrants, such as crospovidone or croscarmellose sodium, facilitate the breakdown of the tablet into smaller particles upon contact with bodily fluids. Lubricants, including magnesium stearate or talc, reduce friction between the tablet and the tablet press, ensuring smooth ejection. Glidants, like colloidal silicon dioxide, improve the flow properties of the powder mixture, enhancing the tableting process. The choice of tablettenbindemittel depends on the specific requirements of the drug product, including its stability, dissolution rate, and mechanical properties. The selection and optimization of tablettenbindemittel are essential for the development of effective and safe tablet formulations.