tSNAREproteiinit

tSNARE proteins are a crucial class of proteins involved in intracellular membrane trafficking. They are integral membrane proteins that play a key role in the specific fusion of transport vesicles with their target compartments. The name "SNARE" is an acronym for SNAP (Soluble NSF Attachment Protein) REceptor. tSNAREs are located on the target membrane, as opposed to vSNAREs which are found on the vesicle membrane. These proteins work in conjunction with vSNAREs to mediate the docking and fusion of vesicles. The interaction between tSNAREs and vSNAREs forms a stable four-helix bundle, which drives the fusion process by bringing the lipid bilayers of the vesicle and target membrane into close proximity. This interaction is highly specific, ensuring that vesicles deliver their cargo to the correct cellular destination. Dysfunction of tSNARE proteins can lead to a variety of cellular defects and is implicated in several diseases. Examples of tSNARE proteins include Syntaxin and SNAP-25, which are well-studied in the context of neurotransmitter release at synapses. Their precise function is essential for maintaining cellular organization and communication.