synthesizability
Synthesizability refers to the practicality of constructing a chemical compound or material from available starting materials and standard laboratory methods. It encompasses considerations of feasibility, safety, cost, and scalability within current scientific capabilities and regulatory environments. Synthesizability is not a measure of a molecule’s existence or its theoretical appeal, but of how readily a synthesis can be implemented in practice.
Several factors influence synthesizability. The number of synthetic steps, average and overall yields, and the structural
Assessment methods combine qualitative and quantitative approaches. Cheminformatics develops synthetic accessibility scores and other complexity metrics
Applications of synthesizability assessments include guiding library design in drug discovery and materials science, prioritizing molecules