succinylCoAaketoasetaattitransferaasi

Succinyl-CoA:acetoacetate transferase is a mitochondrial enzyme responsible for catalyzing the transfer of succinyl-CoA to acetoacetate, forming succinyl-CoA:acetoacetate. This reaction is an essential step in the metabolism of ketone bodies, particularly in the liver.

The enzyme was first discovered in the liver mitochondria of rabbits and was isolated and purified in the early 1970s. Succinyl-CoA:acetoacetate transferase was found to be a homodimeric protein consisting of 33 kDa subunits, with a molecular weight of approximately 57 kDa. The enzyme requires acetyl-CoA, succinyl-CoA, and coenzyme A (CoA) as substrates, and its activity is highly dependent on the concentration of these substrates.

In the presence of succinyl-CoA and acetoacetate, succinyl-CoA:acetoacetate transferase catalyzes the transfer of succinyl-CoA to acetoacetate, forming succinyl-CoA:acetoacetate. This reaction is significant in ketone body metabolism, as it allows for the formation of succinyl-CoA:acetoacetate from succinyl-CoA and acetoacetate. The succinyl-CoA:acetoacetate reaction is a crucial step in the utilization of ketone bodies by the liver and other tissues.

Succinyl-CoA:acetoacetate transferase is most active in the liver mitochondria, but it has also been detected in other tissues, including the kidney and brain. The enzyme's activity is highly regulated by various factors, including the concentration of substrates, pH, and the presence of other metabolic intermediates.

Succinyl-CoA:acetoacetate transferase plays a key role in regulating ketone body metabolism and is an essential component of the liver's ability to metabolize ketone bodies efficiently.