stoppcapprótein
Stop-codon readthrough, also known as stop codon readthrough or ribosomal frameshifting, is a biological process in which the translation machinery of a cell (the ribosome) continues to synthesize a polypeptide chain beyond a normal stop codon. Normally, a stop codon (UAA, UAG, or UGA) signals the termination of protein synthesis. However, under certain conditions, the ribosome can misinterpret these codons, incorporating an amino acid and extending the polypeptide chain. This can lead to the production of a longer protein variant, often with altered or additional functions.
Several factors can promote stop-codon readthrough. These include specific sequences in the messenger RNA (mRNA) adjacent
Stop-codon readthrough is observed in a variety of organisms, from bacteria to eukaryotes, and plays a role