senescência

Senescência is a biological process of aging and deterioration that affects cells, tissues, and organisms. In cellular senescence, cells stop dividing and enter a state of permanent growth arrest. This can be triggered by various stressors, including DNA damage, telomere shortening, and oncogene activation. While initially a protective mechanism against cancer, the accumulation of senescent cells over time can contribute to age-related diseases and tissue dysfunction.

At the organismal level, senescence encompasses the decline in physiological functions that occurs with age. This includes reduced mobility, impaired immune response, and increased susceptibility to disease. The exact mechanisms underlying organismal senescence are complex and involve a combination of genetic, environmental, and stochastic factors. Research into senescencia aims to understand its role in aging and to develop interventions that can mitigate its negative consequences. Strategies such as senolytic therapies, which selectively eliminate senescent cells, are being explored as potential treatments for age-related conditions.