sec141
SEC141 is a protein-coding gene located on chromosome 14, specifically at position 14q11.2. It is a member of the Sec14 family of proteins, which are involved in the transport of proteins across membranes. SEC141 encodes for a protein that plays a crucial role in the endoplasmic reticulum (ER) to Golgi transport pathway. This protein is essential for the formation and maintenance of the ER-Golgi intermediate compartment (ERGIC), a critical organelle involved in protein sorting and trafficking.
The SEC141 protein is a component of the COPII coat, which is responsible for the formation of
Mutations in the SEC141 gene have been associated with various genetic disorders, including Charcot-Marie-Tooth disease type
Research on the SEC141 protein and its role in protein transport continues to be an active area