samplesfixation
Samples fixation is the set of techniques used to preserve biological or chemical samples in a state close to their native condition by stabilizing structures and immobilizing components. The aim is to prevent degradation, autolysis, and morphological change so that subsequent analyses yield reliable data about the sample’s composition and organization.
Fixation methods are broadly categorized as chemical, physical, or a combination. Chemical fixatives commonly include aldehyde-based
The choice of fixative affects downstream analyses. Fixatives can alter antigenicity, enzymatic activity, or nucleic acid
Applications span histology, pathology, and research across cell biology and microbiology. Fixed and appropriately prepared samples
See also: fixation in microscopy, histology, immunohistochemistry, cryofixation, FFPE.