sPLA2IIF

Secreted phospholipase A2 group IIF, also known as sPLA2IIF or PLA2G2F, is a calcium-dependent enzyme. It belongs to the phospholipase A2 superfamily, which are characterized by their ability to hydrolyze ester bonds at the sn-2 position of phospholipids. This enzymatic activity releases a fatty acid and a lysophospholipid. sPLA2IIF specifically targets phospholipids and plays a role in lipid metabolism and inflammatory processes.

The gene encoding sPLA2IIF is located on chromosome 15 in humans. The protein is secreted from cells and circulates in extracellular fluids. Its expression and activity are regulated by various factors, including inflammatory cytokines. sPLA2IIF is thought to contribute to inflammatory responses by generating lipid mediators such as arachidonic acid, a precursor to prostaglandins and leukotrienes.

Research has investigated the involvement of sPLA2IIF in a range of physiological and pathological conditions. Its role in inflammation, both acute and chronic, has been a significant focus. Additionally, studies have explored its potential involvement in diseases like arthritis, atherosclerosis, and certain types of cancer. The precise mechanisms by which sPLA2IIF exerts its effects and its full spectrum of biological functions are still areas of ongoing research. Understanding sPLA2IIF's activity is crucial for potentially developing therapeutic strategies targeting inflammatory diseases.