sPLA2IIA
Phospholipase A2, group IIA, also known as sPLA2IIA, is an enzyme that plays a role in the hydrolysis of phospholipids. Specifically, it catalyzes the release of a fatty acid from the sn-2 position of glycerol in phospholipids, generating a lysophospholipid and a free fatty acid. This enzyme is a member of the secreted phospholipase A2 superfamily, characterized by a conserved catalyticAsp-His-Ser triad and a Cys-Cys-X-Cys-Cys motif.
sPLA2IIA is found in various biological fluids, including plasma, synovial fluid, and pancreatic juice. Its expression
Beyond inflammation, sPLA2IIA has been implicated in other physiological and pathological conditions. These include cardiovascular disease,