qB01

qB01 is a protein-coding gene located on the long arm of chromosome 11 in humans. It is part of the BCL2 family of genes, which are involved in the regulation of apoptosis, or programmed cell death. The qB01 gene encodes a protein called BCL2-like 1 (BCL2L1), also known as Bim.

BCL2L1 is a pro-apoptotic protein, meaning it promotes cell death. It is a member of the BCL2 family, which includes both pro-apoptotic and anti-apoptotic proteins. BCL2L1 plays a crucial role in various biological processes, including cell differentiation, development, and immune response.

Mutations in the qB01 gene have been associated with several diseases, including chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL). In CLL, mutations in BCL2L1 can lead to the accumulation of abnormal B cells, which can result in the development of the disease. In MCL, BCL2L1 mutations can contribute to the uncontrolled proliferation of mantle cells.

Research on the qB01 gene and its encoded protein BCL2L1 continues to advance our understanding of apoptosis regulation and its role in various diseases. Ongoing studies aim to develop targeted therapies for diseases associated with qB01 mutations, potentially improving patient outcomes.