pyrogeny
Pyrogeny refers to the production or induction of fever, typically through the action of substances known as pyrogens. It is a topic of study in immunology, physiology, and clinical medicine and encompasses both exogenous pyrogens from pathogens and endogenous pyrogens produced by the host in response to infection or inflammation.
Mechanism: Pyrogens trigger immune cells, particularly phagocytes such as macrophages, to release cytokines including interleukin-1 (IL-1),
Sources of pyrogens: Exogenous pyrogens include microbial endotoxins (for example, lipopolysaccharide from Gram-negative bacteria), microbial toxins,
Clinical and research relevance: Fever is a common clinical symptom and can reflect the presence of infectious
Etymology and scope: The term derives from Greek roots meaning “fire” and “to be born.” In practice,