psoraleens

Psoraleens are a group of naturally occurring compounds found in various plants, particularly in the legume family. They are known for their ability to inhibit the enzyme DNA polymerase, which is crucial for DNA replication and repair. This inhibition can lead to the formation of DNA cross-links, which are harmful to cells and can ultimately cause cell death. Psoraleens are commonly used in photochemotherapy, a treatment method that uses light to activate the compound and induce cell death in cancer cells. The most well-known psoralen is 8-methoxysoralen, which is used in the treatment of psoriasis and other skin conditions. Psoraleens are also found in some foods, such as fava beans and soybeans, and have been studied for their potential health benefits, including anti-inflammatory and antioxidant properties. However, their use in photochemotherapy has been associated with side effects, such as skin sensitivity to sunlight and an increased risk of skin cancer. Therefore, the use of psoraleens in medicine and food is carefully regulated to ensure their safe and effective use.