protonpumpák

Proton pumpák, often referred to as proton pump inhibitors (PPIs), are a class of drugs that significantly reduce the production of stomach acid. They work by irreversibly blocking the action of the H+/K+-ATPase enzyme system, also known as the "proton pump," which is located in the parietal cells of the stomach lining. This enzyme is the final step in the secretion of gastric acid. By inhibiting this pump, PPIs effectively decrease the amount of acid released into the stomach, regardless of the stimulus.

PPIs are widely prescribed for a variety of gastrointestinal conditions where excess stomach acid is a contributing factor. These include gastroesophageal reflux disease (GERD), peptic ulcers (gastric and duodenal), Zollinger-Ellison syndrome, and as part of treatment regimens for Helicobacter pylori infections. They are generally considered safe and effective when used as directed. Common side effects are usually mild and can include headache, diarrhea, constipation, and abdominal pain. However, long-term use has been associated with potential risks such as vitamin B12 deficiency, magnesium deficiency, and an increased risk of certain infections like Clostridium difficile. Proton pumpák are typically taken orally, often before a meal, to maximize their effectiveness.