peritubulärsubstans

Peritubularsubstans refers to the material found in the interstitial space surrounding the renal tubules in the kidney. This space is not a hollow cavity but rather a complex matrix filled with cells and extracellular components. The peritubular interstitium plays a crucial role in supporting tubule function and is involved in various physiological processes.

The peritubularsubstans consists primarily of interstitial cells, fibroblasts, macrophages, and endothelial cells, along with a dense network of extracellular matrix proteins such as collagen, fibronectin, and proteoglycans. This matrix provides structural support to the tubules and facilitates the exchange of substances between the blood and the tubular fluid. The interstitial cells are metabolically active and are known to produce growth factors and cytokines that influence tubule function and repair.

Several vital functions are attributed to the peritubularsubstans. It is the primary site for reabsorption of water and solutes from the tubular lumen into the peritubular capillaries. The extensive capillary network within the interstitium allows for efficient transport of these substances. Furthermore, the peritubular interstitium is involved in the secretion of certain substances into the tubular fluid, contributing to waste removal and electrolyte balance. Inflammatory and fibrotic processes that lead to kidney disease often originate or are significantly influenced by changes within the peritubularsubstans. Alterations in its composition and cellularity can impair kidney function and contribute to the progression of renal pathology.