p70
p70 is a term used in biology as a shorthand for proteins with an approximate molecular mass of 70 kilodaltons, and as a label in various gene or protein names. It is not a single universal protein but a naming convention that appears in multiple contexts across species and research areas. The most widely known use is p70 S6 kinase, commonly abbreviated p70S6K, a serine/threonine kinase that phosphorylates the ribosomal protein S6 and other substrates to promote protein synthesis and cell growth. p70S6K exists mainly as two isoforms, S6K1 and S6K2, and lies downstream of the mTOR signaling pathway; it is activated by growth factors and nutrients through phosphorylation by mTOR complex 1 and, in many cases, by PDK1. In cells, p70S6K regulates translation initiation, ribosome biogenesis, and metabolism; aberrant activity is associated with cancer and metabolic diseases.
Beyond p70S6K, the label p70 may refer to other 70-kDa proteins in different organisms, including components