osteoclastceller
Osteoclastceller, or osteoclasts, are multinucleated cells responsible for bone resorption. They originate from hematopoietic precursors of the monocyte/macrophage lineage and are located on the bone surface in regions of remodeling.
Osteoclastogenesis requires macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor kappa-B ligand (RANKL). RANKL
A mature osteoclast forms a sealing zone and a ruffled border on the resorption surface. It acidifies
Osteoclast activity is integrated with osteoblast activity during bone remodeling, and is modulated by hormonal and
Clinical relevance: Excessive osteoclast activity contributes to osteoporosis and inflammatory bone loss. Therapeutic approaches include denosumab,