ortholinked
Ortholinked is a term used primarily in bioinformatics to describe datasets, analyses, or networks in which elements such as genes or proteins from different species are linked by orthology relationships. The linking aims to preserve evolutionary relationships so that functional information and annotations can be transferred or compared across species. The term is not yet part of a formal standard and can be used variably depending on context.
Etymology and scope: The prefix ortho- derives from Greek, here referencing orthology rather than literal physical
Applications: Ortholinked datasets are used in comparative genomics, functional annotation transfer, phylogenomic analysis, and cross-species pathway
Data standards and challenges: Key challenges include inaccuracies in orthology calls, gene duplication events, and lineage-specific
Relation to other concepts: Ortholinked relates to orthology and paralogy, and to broader topics in comparative
History and reception: The term appears in some niche discussions as a shorthand for cross-species orthology-linked