olopatadine

Olopatadine is a medication used to treat allergic conditions, notably allergic conjunctivitis and allergic rhinitis. It is a selective antihistamine of the H1 receptor class with additional mast cell stabilizing properties, which helps to reduce itching, redness, and other symptoms by blocking histamine effects and limiting release of inflammatory mediators.

Formulations include ophthalmic solutions for the eyes and a nasal spray for the nose. Ophthalmic olopatadine is available in concentrations such as 0.1% and 0.2% and is marketed under brand names such as Patanol (0.1%) and Pataday (0.2%) in some markets. The nasal spray (olopatadine) is available in nasal formulations, marketed as Patanase in some regions.

Indications: treatment of ocular itching associated with seasonal and perennial allergic conjunctivitis; relief of symptoms of allergic rhinitis (nasal congestion, sneezing, itching, runny nose) in suitable patients.

Administration: The ophthalmic product is instilled as one or two drops into the affected eye(s) as directed. The nasal spray is used as directed; dosing schedules vary by product and patient age.

Side effects: For eye drops, common local effects include temporary stinging, burning, or dry-eye sensation; unusually, a bitter taste may occur after nasal administration. Systemic side effects are uncommon due to low systemic exposure.

Contraindications and cautions: Contraindicated in those with known hypersensitivity to olopatadine or any components. Use in pregnancy and lactation only after discussing risks with a clinician. As with all medications, interactions are limited by low systemic absorption.