nukleotidiexkisionreparoinnilla
Nukleotidiexkisionreparoinnilla, also known as nucleotide excision repair (NER), is a crucial cellular mechanism that repairs damaged DNA. It is particularly effective at removing bulky, helix-distorting lesions such as those caused by UV radiation, chemical mutagens, and certain DNA adducts. NER operates through a multi-step process involving several protein complexes.
The pathway begins with damage recognition. In eukaryotes, two main sub-pathways exist: global genome NER (GG-NER)
Once damage is detected, a multi-subunit complex, including XPB and XPD helicases, unwinds the DNA around the
Finally, DNA polymerase synthesizes new DNA to fill the gap, using the undamaged strand as a template.