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Nome is a city and port in the Nome Census Area of western Alaska, United States, located on the southern coast of the Seward Peninsula along the Bering Sea. It serves as the regional hub for western Alaska, supporting government services, healthcare, education, and commercial fishing.

Nome grew rapidly during the Nome Gold Rush of 1899–1900, when prospectors settled along the coast and in nearby hills. It was incorporated as a city in the early 20th century and developed as a transportation and supply center for surrounding communities. In 1925, Nome was the terminus of the serum run to Nome, a relay that delivered diphtheria antitoxin to combat an outbreak.

Nome lies on the Bering Sea coast facing the Norton Sound and is near Cape Nome. The area experiences a subarctic climate with strong maritime influence, long cold winters and cool summers. Permafrost underlies portions of the landscape, and fog and wind are common.

The population includes Indigenous Inupiat residents and descendants of settlers, with the economy centered on government, health care, education, tourism, and seafood processing. Fishing, traditional crafts, and seasonal work also play roles in the local economy.

Nome is a regional cultural center with arts, museums, and events such as the finish of the annual Iditarod Trail Sled Dog Race. The primary access is by air through Nome Airport, with maritime access via a commercial port; there is no permanent road connection to other parts of Alaska.