neuroblast

A neuroblast is a cell that is committed to becoming a neuron. It is a type of stem cell found in the developing nervous system. Neuroblasts are produced from neural stem cells, which are multipotent and can differentiate into various cell types of the nervous system, including neurons and glial cells. However, once a neural stem cell differentiates into a neuroblast, its fate is largely determined, and it will primarily give rise to neurons.

Neuroblasts are characterized by their ability to proliferate and then differentiate into mature neurons. This process involves a series of molecular and morphological changes. They migrate from their birthplace to their final destinations within the developing brain or nervous system. During migration, they can be influenced by various signaling cues. Once they reach their target locations, they undergo terminal differentiation, acquiring the specific characteristics of different neuronal subtypes.

The generation of neuroblasts is a crucial step in neurogenesis, the process by which new neurons are formed. This process occurs extensively during embryonic development but also continues in specific regions of the adult brain, such as the subventricular zone and the hippocampus. The study of neuroblasts is important for understanding brain development, neural repair, and the origins of neurological disorders.