metalloproteinase17

Metalloproteinase 17, also known as MMP17 or membrane type 2 matrix metalloproteinase (MT2-MMP), is an enzyme belonging to the matrix metalloproteinase family. These enzymes are zinc-dependent endopeptidases involved in the breakdown of extracellular matrix proteins. MMP17 is a type II transmembrane protein, meaning it is anchored to the cell membrane. Its primary function is to cleave various components of the extracellular matrix, including collagen, gelatin, and other matrix proteins.

MMP17 is expressed in a variety of tissues and cell types, and its activity is regulated by several mechanisms. It is known to play a role in processes such as tissue remodeling, cell migration, and wound healing. Aberrant expression or activity of MMP17 has been implicated in several pathological conditions, including cancer, arthritis, and cardiovascular diseases. In cancer, MMP17 is thought to contribute to tumor growth, invasion, and metastasis by degrading the extracellular matrix, facilitating tumor cell movement. Research is ongoing to fully understand its precise roles in both normal physiological processes and disease states.