matrixeffect
Matrix effect refers to the influence of a sample's constituent matrix on the measurement of target analytes. It is a term commonly used in analytical chemistry and related fields to describe how components of the sample other than the analyte can alter analytical signals or responses.
Causes vary by technique but commonly include ion suppression or enhancement in mass spectrometry, changes in
In quantitative analyses, matrix effects can bias results, leading to under- or overestimation of analyte concentrations
Mitigation strategies include matrix-matched calibration, the use of internal standards (preferably isotopically labeled), standard addition experiments,
Matrix effects are routinely considered in fields such as bioanalysis, clinical chemistry, environmental monitoring, and food
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