mannose6fosfat
Mannose-6-phosphate is a phosphorylated derivative of the sugar mannose that serves as a key targeting tag for lysosomal enzymes in many eukaryotic cells. In its mature form, the phosphate group is attached at the 6-position of mannose residues on lysosomal hydrolases that are being prepared for transport to the lysosome. This label is essential for proper enzyme sorting and delivery within the endomembrane system.
Biosynthesis and maturation occur in the Golgi apparatus. The enzyme N-acetylglucosamine-1-phosphotransferase transfers a phospho-N-acetylglucosamine group to
Mannose-6-phosphate directs lysosomal enzymes to the lysosome through interaction with mannose-6-phosphate receptors. There are cation-dependent and
Clinical relevance includes the lysosomal storage disorder I-cell disease (mucolipidosis II), caused by deficiency of the