mMDH

mMDH, also known as mitochondrial malate dehydrogenase, is an enzyme found in the mitochondria of eukaryotic cells. It plays a crucial role in the citric acid cycle, also known as the Krebs cycle or TCA cycle. This cycle is a central metabolic pathway for cellular respiration, generating energy in the form of ATP. mMDH specifically catalyzes the interconversion of malate and oxaloacetate. This reaction involves the reduction of NAD+ to NADH, a key electron carrier used in the electron transport chain to produce ATP.

The mMDH enzyme is encoded by the MDHM gene. It is part of a family of malate dehydrogenase enzymes, with other forms found in different cellular compartments. The mitochondrial location of mMDH is essential for its function within the citric acid cycle, which also takes place in the mitochondrial matrix. The activity of mMDH is regulated by the availability of its substrates and products, as well as by cellular energy demands. Dysregulation or deficiency in mMDH activity can have implications for cellular metabolism and energy production, and has been linked to certain metabolic disorders. Its presence and function are vital for the efficient breakdown of carbohydrates, fats, and proteins to fuel cellular processes.