leukotrieneiksi
Leukotrienes are a group of lipid mediators derived from arachidonic acid, a polyunsaturated fatty acid found in cell membranes. They play a significant role in inflammatory and allergic responses, particularly in conditions such as asthma, allergic rhinitis, and other allergic diseases. The biosynthesis of leukotrienes begins with the conversion of arachidonic acid by the enzyme 5-lipoxygenase (5-LO), which initiates a cascade leading to the formation of various leukotrienes, including leukotriene A4 (LTA4), leukotriene B4 (LTB4), leukotriene C4 (LTC4), leukotriene D4 (LTD4), and leukotriene E4 (LTE4).
Leukotriene B4 is primarily involved in the recruitment of neutrophils, a type of white blood cell, to
Leukotrienes are synthesized and released by various immune cells, including mast cells, eosinophils, basophils, and macrophages.
In clinical practice, leukotriene modifiers, such as montelukast, zafirlukast, and zileuton, are used to treat asthma