lepirudinilla
Lepirudinilla is a synthetic direct thrombin inhibitor. It is a recombinant hirudin analog, derived from the leech salivary gland protein hirudin. Lepirudinilla works by binding directly to thrombin, inhibiting its enzymatic activity and preventing the conversion of fibrinogen to fibrin, a key step in clot formation.
It was developed for the treatment of heparin-induced thrombocytopenia (HIT), a serious immune-mediated complication of heparin
Lepirudinilla is administered intravenously. Its pharmacokinetics are characterized by rapid onset and offset of action, with