korjaussynteesiä
Korjaussynteesi, also known as repair synthesis or post-replication repair, is a DNA repair mechanism that operates during or shortly after DNA replication. Its primary function is to correct errors that arise when the DNA replication machinery encounters a lesion or damage in the template strand. When a replication fork stalls due to a lesion, the new DNA strand might be synthesized incorrectly, leaving a gap opposite the damaged base. Korjaussynteesi is a pathway that fills these gaps.
This process typically involves several steps. First, the stalled replication fork is processed. Then, a gap
Korjaussynteesi is crucial for maintaining genomic integrity. Defects in this repair pathway can lead to increased