konformaatiolakia
Konformaatiolakia is the Finnish term for conformational laws, a family of principles in chemistry and molecular modeling that describe how molecules adopt and interconvert among different shapes, or conformations, under specific conditions. Rather than a single codified statute, konformaatiolakia function as a conceptual framework used to interpret and predict conformational preferences in small molecules, macromolecules, and biomolecules.
The core ideas involve an energy landscape generated by torsional strain, steric interactions, electrostatics, and solvent
Applications of konformaatiolakia span drug design, where predicting active conformations informs binding hypotheses; organic synthesis, where
Limitations and debate accompany the concept, as real systems can exhibit non-equilibrium behavior, long-range and cooperative
See also: conformational analysis, energy landscape, torsion angle, Boltzmann distribution.