kerataanisulfaattia

Kerataanisulfaattia, also known as keratan sulfate, is a glycosaminoglycan found in connective tissues. It is a long, unbranched polysaccharide composed of repeating disaccharide units. These units typically consist of galactose and N-acetylglucosamine. The specific structure can vary slightly depending on the location in the body.

Keratan sulfate is particularly abundant in the cornea of the eye, where it plays a crucial role in maintaining corneal transparency and hydration. It is also found in cartilage, bone, and the intervertebral discs, contributing to the structural integrity and shock-absorbing properties of these tissues. Unlike many other glycosaminoglycans, keratan sulfate is not typically sulfated at every repeating unit, and the position of sulfation can also vary.

The synthesis of keratan sulfate occurs in the Golgi apparatus. Its biological functions are diverse, including regulating water retention, providing lubrication, and influencing cell signaling. Degradation is carried out by specific enzymes. Disorders affecting keratan sulfate metabolism can lead to various health issues, particularly affecting vision and skeletal health. Research continues to explore the multifaceted roles of keratan sulfate in physiological and pathological processes.