jak13

JAK13 is not a widely recognized gene symbol in standard human gene nomenclature. In human and vertebrate biology, the JAK family comprises four established members: JAK1, JAK2, JAK3, and TYK2. There is no officially assigned JAK13 gene in major databases such as HGNC, Ensembl, or NCBI Gene. In some species or datasets, a label like “jak13” may appear as a placeholder, a misannotation, a pseudogene, or a paralog that has not been functionally characterized. When encountered, researchers should verify the symbol against authoritative resources and consider alternative explanations such as mislabeling of JAK3 or a species-specific gene.

Overview of JAK family: Janus kinases are non-receptor protein tyrosine kinases that associate with type I and type II cytokine receptors. They contain a FERM domain for receptor binding, an SH2-like domain, a pseudokinase domain (JH2) involved in regulation, and a catalytic kinase domain (JH1). Upon cytokine receptor engagement, JAKs transphosphorylate and recruit STAT proteins to propagate signaling, regulating immune cell development, hematopoiesis, and inflammatory responses. Dysregulation of JAK signaling is linked to myeloproliferative disorders, autoimmune diseases, and cancer; several JAK inhibitors (e.g., tofacitinib, ruxolitinib) are approved for clinical use.

For precise information, consult HGNC, Ensembl, or NCBI Gene to confirm current gene symbols and orthology across species.