ionekanalkoblede
Ionekoblede, often translated as ion channel coupled receptors or ionotropic receptors, are a class of cell surface receptors that are directly linked to ion channels. Unlike metabotropic receptors, which rely on intracellular signaling cascades to modulate ion channel activity, ionekanalkoblede form part of the ion channel itself. When a specific ligand, such as a neurotransmitter, binds to the extracellular domain of the receptor, it induces a conformational change. This change directly opens or closes the integral ion pore, allowing specific ions (like sodium, potassium, calcium, or chloride) to flow across the cell membrane.
This rapid ion flux leads to a rapid change in the membrane potential of the cell, a