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iodoform

Iodoform, with the chemical formula CHI3, is a pale yellow crystalline solid known for its distinctive antiseptic odor. It is sparingly soluble in water and more readily soluble in organic solvents. It decomposes on heating, with a melting point around 119–121 °C.

Iodoform is typically prepared in the laboratory by oxidizing or halogenating compounds bearing a methyl ketone

The compound is best known for its role in the iodoform test, a qualitative chemical test used

Historically, iodoform has been used as an antiseptic and disinfectant, particularly in medical preparations, though its

Safety considerations are important when handling iodoform. It can be toxic if ingested and may irritate the

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or
a
primary/secondary
alcohol
that
can
be
converted
to
such
a
ketone.
The
classical
iodoform
reaction
involves
treating
a
methyl
ketone
(R-CO-CH3)
or
ethanol
with
iodine
in
a
strongly
basic
medium:
R-CO-CH3
+
3
I2
+
4
OH-
→
RCOO-
+
CHI3
+
3
I-
+
3
H2O.
The
reaction
yields
a
yellow
precipitate
of
iodoform
(CHI3)
and
a
carboxylate
salt.
to
identify
methyl
ketones
and
ethanol.
A
positive
test
is
indicated
by
the
formation
of
a
pale
yellow
CHI3
precipitate.
use
has
declined
due
to
odor,
Tg
toxicity
concerns,
and
the
availability
of
safer
alternatives.
It
remains
important
in
organic
synthesis
as
a
reagent
and
as
a
historical
demonstration
of
the
selective
cleavage
of
a
methyl
group
adjacent
to
a
carbonyl.
skin,
eyes,
and
respiratory
tract.
Proper
lab
practices,
including
use
of
gloves
and
good
ventilation,
are
recommended,
with
appropriate
disposal
of
waste.