intrbtis

Intrbtis is a term that has emerged in the early 2020s within the field of computational biology and bioinformatics, particularly in studies focusing on protein interaction networks. The acronym stands for Integrated Network-Based Ranking Tool for Interaction Sites, and it refers to software designed to prioritize key protein interaction sites by integrating multiple data sources, including structural information, evolutionary conservation, and functional annotation. The tool employs machine learning algorithms to assign confidence scores to candidate interaction residues and visualizes the results within a network graph.

The initial release of intrbtis was documented in a 2021 peer‑reviewed article in the journal Bioinformatics, where the authors demonstrated its utility in identifying potential drug targets in viral proteins. Subsequent versions of the software added support for transcriptomic integration and user‑defined weighting schemes. While intrbtis has gained traction in academic communities studying protein–protein complexes, it remains a niche application and is not widely adopted outside specialized research groups. Community contributions and updates continue to be published in open source repositories, and the developers encourage collaboration to expand its capabilities for diverse omics datasets.