interferongammadriven
Interferon-gamma-driven refers to cellular responses, gene expression programs, and physiological outcomes that are largely regulated by the cytokine interferon-gamma (IFN-γ). It describes biological processes in which IFN-γ is the primary driver, produced by immune cells such as natural killer cells and T lymphocytes and acting to shape both innate and adaptive immunity.
Mechanism: IFN-γ signals through the IFN-γ receptor (IFNGR1/IFNGR2), activating the JAK1/JAK2-STAT1 pathway. Phosphorylated STAT1 dimerizes, translocates
Physiological and clinical relevance: IFN-γ–driven responses are central to defense against intracellular pathogens (e.g., mycobacteria) and