icilin
Icilin is a synthetic compound that acts as a potent and selective agonist of the transient receptor potential melastatin 8 (TRPM8) ion channel. TRPM8 is a cold-activated cation channel that plays a significant role in thermoreception, pain sensation, and the detection of cold temperatures. Icilin's ability to activate TRPM8 at temperatures above physiological relevance makes it a valuable research tool.
When applied to biological systems, icilin elicits a range of responses associated with TRPM8 activation. These
The development of icilin has provided a crucial chemical probe for understanding the intricate roles of TRPM8.