hyperinsulinemiaklaampatutkimus

Hyperinsulinemia clamp studies, often referred to as euglycemic clamps, are a research tool used to precisely measure insulin sensitivity in an individual. This technique involves a continuous infusion of insulin at a specific rate to maintain a target blood glucose level, typically around 90 mg/dL. To achieve this, a second infusion of glucose is administered at a variable rate, precisely matching the amount of glucose the body is consuming in response to the insulin. The rate of glucose infusion required to maintain euglycemia is a direct measure of insulin sensitivity. A higher glucose infusion rate indicates greater insulin sensitivity, meaning the body's tissues are effectively responding to insulin to take up glucose. Conversely, a lower glucose infusion rate suggests insulin resistance. These studies are considered the gold standard for assessing insulin action and are used in research settings to investigate the mechanisms of insulin resistance in conditions such as type 2 diabetes, obesity, and metabolic syndrome. They are invasive and time-consuming, typically requiring several hours of monitoring in a clinical research unit. The data collected allows for the quantification of peripheral insulin sensitivity, as well as to some extent, hepatic insulin sensitivity.